Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 105, Issue 8, Pages 1095-1101Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2011.05.005
Keywords
Platinum(II) complexes; Antitumor activity; Alkoxycarboxylates; Toxicity; Leaving groups
Funding
- National Natural Science Foundation of China [20971022, 20471027]
- Six Top Talents Funding of Jiangsu Province [2008046]
- National Science and Technology Major Foundation of China [2010ZX09401-401]
- Southeast University
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Five oxaliplatin-typed platinum complexes containing trans-1R, 2R-diaminocyclohexane chelating platinum cores, characteristic of linear or branched alkoxycarboxylates as leaving groups, were biologically evaluated. These compounds showed higher antitumor activity, lower toxicity in vivo than cisplatin or oxaliplatin. And the results revealed that the antitumor activity and interaction with DNA of these compounds were highly related to the nature of leaving groups. Among these complexes, 5a, cis-(trans-1R, 2R-diaminocyclohexane) bis (2-tert-butoxyacetate) platinum(II), showed the highest antitumor activity and the lowest toxicity. (C) 2011 Elsevier Inc. All rights reserved.
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