Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 105, Issue 11, Pages 1513-1517Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2011.07.001
Keywords
Al toxicity; Astrocytes; Fat factories; Globular; ATP; L-carnitine
Funding
- Laurentian University and Industry Canada
- NSERC
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Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders. (C) 2011 Elsevier Inc. All rights reserved.
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