Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 105, Issue 3, Pages 490-496Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2010.08.014
Keywords
Clioquinol; Alzheimer's disease; Metal ions; Stability constants
Funding
- Centre National de la Recherche Scientifique (CNRS) [UMR 7177]
- Croatian Ministry of Science, Education and Sport
- French Embassy in Zagreb
- Croatian National Foundation for Science
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We report here a thorough physico-chemical study of the coordination properties of clioquinol, an oxine-type active neurological drug in Alzheimer's disease, toward biologically relevant divalent metal ions (Cu, Zn, Ni, Co and Mn). Using a fruitful combination of electrospray mass spectrometry, absorption spectrophotometry and potentiometry, we have characterized the mono- and bis-chelated metal ion species. The determination of the stability constants showed a classical thermodynamic behavior along the studied series with the cupric complexes being by far the most stable species. Our data are discussed within the scope of Alzheimer's disease. (C) 2010 Elsevier Inc. All rights reserved.
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