4.6 Article

A fast ruthenium polypyridine cage complex photoreleases glutamate with visible or IR light in one and two photon regimes

Journal

JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 104, Issue 4, Pages 418-422

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2009.12.004

Keywords

Caged compounds; Phototriggers; Two photon; Glutamate; Neuron; Ruthenium

Funding

  1. CONICET
  2. UBA
  3. NEI
  4. STV office of Columbia University
  5. Kavli institute for Brain Science

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We introduce a new caged glutamate, based in a ruthenium bipyridyl core, that undergoes heterolytic cleavage after irradiation with visible light with wavelengths up to 532 rim, yielding free glutamate in less than 50 ns. Glutamate photorelease occurs also efficiently following two-photon (2P) excitation at 800 nm, and has a functional cross section of 0.14 GM. (C) 2009 Elsevier Inc. All rights reserved.

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