Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 104, Issue 10, Pages 1079-1083Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2010.06.005
Keywords
Falcipain-2; Gold(I) complexes; P. falciparum; Thiosemicarbazones
Funding
- AuTEK (Mintek and Harmony gold, South Africa)
- South African National Research Foundation (NRF)
- University of Cape Town
- South African Research Chairs Initiative of the Department of Science and Technology through the NRF
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The reaction of thiosemicarbazones (TSCs) with [Au-I(THT)CI], THT = tetrahydrothiophene, has been investigated. The resulting gold(I) complexes have been characterized by a range of spectroscopic techniques: NMR spectroscopy. mass spectrometry, microanalysis and infrared spectroscopy. The in vitro antimalarial data for gold(I) TSC complexes suggests that coordination of gold(I) to TSCs enhanced their efficacy against the malaria parasite Plasmodium falciparum and their inhibition of the parasite cysteine protease falcipain-2. (c) 2010 Elsevier Inc. All rights reserved.
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