4.6 Article

Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity

Journal

JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 103, Issue 9, Pages 1196-1203

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2009.05.017

Keywords

Coumarin; Copper; Metal complexes; X-ray crystal structures; Antifungal

Funding

  1. European Social Fund
  2. EMBARK

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The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a-3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B. (C) 2009 Elsevier Inc. All rights reserved.

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