Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 103, Issue 11, Pages 1563-1570Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2009.07.018
Keywords
Aluminium; Renin; Kidneys; Essential hypertension; Urinary excretion; Gene expression
Funding
- Ministry of Health, Labour and Welfare of Japan
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The excretion of aluminium in urine was significantly increased after intake of analgesics containing aluminium, confirming increased absorption and hence exposure to aluminium with such medication. The effect of aluminium on the kidney was further investigated by study of gene expression in mice. After a single dose of aluminium, an up-regulation of renin gene was found by DNA sequencing of the products of differential display analysis. The up-regulation of renin was confirmed by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting experiments in the dose dependent treatments and the time course observation after aluminium citrate injection. The up-regulation of the renin expression by aluminium is a strong indication of the influence of aluminium on the renin-angiotensin-aldosterone-system, resulting in possible induction of essential hypertension. (C) 2009 Elsevier Inc. All rights reserved.
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