Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 102, Issue 1, Pages 26-32Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2007.06.033
Keywords
polyether ionophore antibiotics; monensin A; transition metal complexes
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Mononuclear neutral manganese(II) and cobalt(II) complexes with the antibiotic Sodium Monensin A (Mon-Na, 1b) were synthesized and characterized. The crystal structures of M(Mon-Na)(2)Cl-2 center dot H2O (M = Mn, 2; M = Co, 3) were determined by X-ray crystallography. The complexes crystallize in monoclinic space group C2 with a tetrahedrally coordinated transition metal attached to oxygen atoms of deprotonated carboxyl groups of two Sodium Monensin molecules and two chloride ions. The sodium ion remains in the cavity of the ligand and cannot be replaced by Mn(II) or Co(II). The complexes were additionally characterized by different spectroscopic techniques (UV-Visible, EPR, FAB-MS). A preferable octahedral environment around the transition metal centers is observed in polar solvents while the complexes retain their tetrahedral structure in non-polar media. The antimicrobial activity of 1b, 2 and 3 was tested against Gram(+) and Gram(-) bacteria. (c) 2007 Elsevier Inc. All rights reserved.
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