Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 102, Issue 5-6, Pages 1066-1076Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2007.10.016
Keywords
anticancer drugs; DNA binding; electrospray ionization mass spectrometry; pta; arene-ruthenium complexes; bioorganometallic chemistry
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The reactions of arene-metal complexes (arene = p-cymene, benzene or pentamethylcyclopentadienyl, metal = Ru, Rh or Os), including 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine (pta) and chloro co-ligands, with 9-methylguanine, adenine, and a series of nucleosides were studied in water to ascertain the binding modes. The products were characterized by NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS). Tandem mass spectrometry was found to provide excellent information on preferential binding sites. In general, the N7 position on guanine (the most basic site) was found to be the preferred donor atom for coordination to the metal complexes. The X-ray structures of the precursor complexes, [(eta(5)-C(10)H(15))RhCl(pta-Me)(2)]Cl(2), [(eta(6)-Cl(10)H(14))OsCl(pta)(2)]Cl, and [(eta(6)-C(6)H(6))OsCl(2)(CH(3)CN)], are also reported. (C) 2007 Elsevier Inc. All rights reserved.
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