Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 102, Issue 10, Pages 1932-1941Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2008.07.001
Keywords
manganese porphyrins; beta-halogenated porphyrins; lodosylbenzene; lodobenzene diacetate; cyclohexane hydroxylation
Funding
- The Brazilian Research Council (CNPq
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
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A homologous series of beta-brominated porphyrins derived from meso-tetrakis(4-carbomethoxyphenyl)porphyrinatomanganese(III) chloride, i.e., Mn(III)(BrxTCMPP)Cl (x = 0,2,4,6, and 8), was prepared and investigated as cytochrome P450 models. Hydroxylations of cyclohexane by iodosylbenzene (PhIO) and ioclobenzene diacetate (Phl(OAc)(2)) in the presence or absence of water were carried out as P450 model reactions. The influence of the degree of beta-bromination of the macrocycle on the UV-vis spectra, the Mn(III)/Mn(II) reduction potential, and the catalytic properties of the Mn(III)(BrxTCMPP)Cl (x = 0, 2,4,6, and 8) series were examined. The catalytic efficiency does not correlate with the Mn(III)/Mn(II) reduction potential and shows a bell-shaped behavior, where the best results are achieved with the hexabrominated complex. Better hydroxylation yields were achieved by using Phl(OAc)2 as oxygen donor, but at expenses of catalyst recovery; addition of water to this system resulted in a increase in the reaction rate. Recycling of the more oxidatively robust complexes Mn(III)(Br6TCMPP)Cl and Mn(III)(Br8TCMPP)Cl is feasible when using PhIO as oxygen donor. Selectivity and UV-vis data suggested that hydroxylation by both PhlO and Phl(OAc)2 Share closely related active species and mechanism. We also show that the Mn(III)/Mn(II) reduction potentials are inappropriate predictors of P450-type activity of Mn porphyrin-catalyzed oxidations. (c) 2008 Elsevier Inc. All rights reserved.
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