Journal
JOURNAL OF INNATE IMMUNITY
Volume 11, Issue 3, Pages 193-204Publisher
KARGER
DOI: 10.1159/000491497
Keywords
Anti-biofilm peptides; Biofilm infections; Physiologically relevant conditions
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Funding
- Canadian Institutes for Health Research [FDN-154287]
- Cystic Fibrosis Canada
- Canada Research Chair in Health and Genomics
- UBC Killam Professorship
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Highly antibiotic resistant, microbial communities, referred to as biofilms, cause various life-threatening infections in humans. At least two-thirds of all clinical infections are biofilm associated, and antibiotic therapy regularly fails to cure patients. Anti-biofilm peptides represent a promising approach to treat these infections by targeting biofilm-specific characteristics such as highly conserved regulatory mechanisms. They are being considered for clinical application and we discuss here key factors in discovery, design, and application, particularly the implementation of host-mimicking conditions, that are required to enable the successful advancement of potent anti-biofilm peptides from the bench to the clinic. (C) 2018 The Author(s) Published by S. Karger AG, Basel
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