Journal
JOURNAL OF INNATE IMMUNITY
Volume 6, Issue 5, Pages 706-712Publisher
KARGER
DOI: 10.1159/000358881
Keywords
Bovine granulocytes; Neutrophil extracellular traps; Enrofloxacin; Cytoskeleton
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Funding
- Akademie fur Tiergesundheit (AfT)
- German Academic Exchange Service (DAAD)
- NCI/NIH [R01 CA136856]
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Several antibiotics are known for their ability to accumulate in neutrophils and thereby modulate the antimicrobial functions of those cells. This study demonstrates for the first time that an antibiotic, namely the fluoroquinolone enrofloxacin, enhances the formation of bovine neutrophil extracellular traps (NETs). Pharmacologically inactivated NADPH oxidase or peptidyl-arginine deiminase-4 distinctly reduced enrofloxacin-induced NET formation. Additionally, when cells were treated with cytochalasin D or nocodazole, the enrofloxacin-mediated NET induction was abolished, indicating that besides oxidative burst and histone citrullination also actin and microtubule polymerization are involved in this process. (C) 2014 S. Karger AG, Basel
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