Journal
JOURNAL OF INNATE IMMUNITY
Volume 6, Issue 4, Pages 553-560Publisher
KARGER
DOI: 10.1159/000357820
Keywords
Neutrophils; Inflammation; Signal regulatory protein alpha; Chemotactic factor; Skin window; Exudate
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Funding
- Swedish Research Council [2012-2702, 2011-3358, 16X-20247]
- King Gustaf V 80-Year Foundation
- Goteborg Rheumatism Association
- Swedish state under the LUA/ALF
- Faculty of Medicine, Umea University
- Young Researcher Award from Umea University
- Grants-in-Aid for Scientific Research [23370061, 25112709] Funding Source: KAKEN
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Signal regulatory protein alpha (SIRP alpha) is a cell surface glycoprotein with inhibitory functions, which may regulate neutrophil transmigration. SIRPa is mobilized to the neutrophil surface from specific granules, gelatinase granules, and secretory vesicles following inflammatory activation in vitro and in vivo. The lack of SIRPa signaling and the ability to up-regulate SIRPa to the cell surface promote neutrophil accumulation during inflammation in vivo. (C) 2014 S. Karger AG, Basel
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