Journal
JOURNAL OF INNATE IMMUNITY
Volume 6, Issue 2, Pages 192-204Publisher
KARGER
DOI: 10.1159/000353734
Keywords
Basement membrane; Coagulation; Hemocyte; Insect immunity; Nematodes; Recognition molecule; Thioester-containing proteins
Categories
Funding
- Swedish Research Council
- STINT (Swedish Foundation for International Cooperation in Research and Higher Education)
- Knut and Alice Wallenberg Foundation
- Swedish Cancer Foundation
- European Social Fund
- state budget of the Czech Republic
- European Union Seventh Framework Program (FP7) [316304]
Ask authors/readers for more resources
Heterorhabditis bacteriophora is an entomopathogenic nematode (EPN) which infects its host by accessing the hemolymph where it releases endosymbiotic bacteria of the species Photorhabdus luminescens. We performed a genome-wide transcriptional analysis of the Drosophila response to EPN infection at the time point at which the nematodes reached the hemolymph either via the cuticle or the gut and the bacteria had started to multiply. Many of the most strongly induced genes have been implicated in immune responses in other infection models. Mapping of the complete set of differentially regulated genes showed the hallmarks of a wound response, but also identified a large fraction of EPN-specific transcripts. Several genes identified by transcriptome profiling or their homologues play protective roles during nematode infections. Genes that positively contribute to controlling nematobacterial infections encode: a homolog of thioester-containing complement protein 3, a basement membrane component (glutactin), a recognition protein (GNBP-like 3) and possibly several small peptides. Of note is that several of these genes have not previously been implicated in immune responses. (C) 2013 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available