Journal
JOURNAL OF INNATE IMMUNITY
Volume 4, Issue 1, Pages 111-116Publisher
KARGER
DOI: 10.1159/000329224
Keywords
Innate; Insect; Peptidoglycan
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Funding
- Swedish Research Council [621-2005-4435]
- Carl Trygger Foundation [09:362]
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It has been much debated how the Drosophila immune system can recognize bacterial peptidoglycan that is often hidden. We show that bacteria separated from Drosophila S2 cells by a semipermeable membrane can upregulate the Imd pathway. Supernatants from exponentially growing but not from stationary-phase bacterial cultures induce antimicrobial peptides. It is also made likely that the shed elicitors are of peptidoglycan nature. Copyright (C) 2011 S. Karger AG, Basel
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