Journal
JOURNAL OF INNATE IMMUNITY
Volume 4, Issue 4, Pages 349-360Publisher
KARGER
DOI: 10.1159/000336844
Keywords
Antimicrobial peptides; Dermcidin; Host defense; Skin innate immune response
Categories
Funding
- Deutsche Forschungsgemeinschaft [SFB766]
Ask authors/readers for more resources
Eccrine sweat glands, which are distributed over the whole bodies of primates and humans, have long been regarded mainly to have a function in thermoregulation. However, the discovery of dermcidin-derived antimicrobial peptides in eccrine sweat demonstrated that sweat actively participates in the constitutive innate immune defense of human skin against infection. In the meantime, a number of studies proved the importance of dermcidin in skin host defense. Several reports also state that peptides processed from the dermcidin precursor protein exhibit a range of other biological functions in neuronal and cancer cells. This review summarizes the evidence gathered until now concerning the expression of dermcidin and the functional relevance of dermcidin-derived peptides. Copyright (C) 2012 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available