Journal
JOURNAL OF INNATE IMMUNITY
Volume 3, Issue 3, Pages 274-279Publisher
KARGER
DOI: 10.1159/000324176
Keywords
Natural killer cells; Viral infection; Innate immunity
Categories
Funding
- National Institutes of Health [AI083000, CA136934, CA047741, CA111807]
- Alliance for Cancer Gene Therapy
- NATIONAL CANCER INSTITUTE [P01CA047741, R01CA111807, R01CA136934] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI083000] Funding Source: NIH RePORTER
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Natural killer (NK) cells, as part of the innate immune system, play a key role in host defense against viral infections. Recent advances have indicated that NK cell activation and function are regulated by the interplay between inhibitory and activating signals. Thus, a better understanding of mechanisms responsible for NK cell activation and function in the control of viral infections will help develop NK cell-based therapies. In this review, we will first discuss how NK cells are activated in response to viral infections. We will then focus on the recruitment of activated NK cells to the site of infection as well as on NK cell effector mechanisms against virally infected cells. Copyright (C) 2011 S. Karger AG, Basel
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