Journal
JOURNAL OF INNATE IMMUNITY
Volume 3, Issue 4, Pages 365-373Publisher
KARGER
DOI: 10.1159/000328505
Keywords
Natural killer cells; Melanoma; NKG2D; Natural cytotoxicity receptors; DNAX accessory molecule-1
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Funding
- Ministry of Science and Innovation of Spain [SAF2006-03687, SAF2009-09711]
- Junta de Extremadura [GRU09156, GRU10104, PRE07047]
- European Regional Development Funds (FEDER)
- Spanish Ministry of Health [PS09/00723]
- Junta de Andalucia [JA0292/07]
- University of Extremadura [ACCIII/22]
- Spanish Network for Research in Infectious Diseases [REIPI RD06/0008]
- [PRI09A029]
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The role of natural killer (NK) cells in tumor immunosurveillance has been recently underlined. A better understanding of the receptor-ligand interactions between NK cells and solid tumor cells is essential for introducing more effective NK cell-based immunotherapy protocols into clinical practice. We previously analyzed the surface expression of ligands for NK cell-activating receptors and costimulatory molecules in a large panel of melanoma cell lines. Although the expression of ligands for NK cell-activating receptors is variable, the majority of melanoma cell lines express ligands for NKG2D and for DNAX accessory molecule-1 (DNAM-1). While the NKG2D receptor has been described as the principal entity responsible for the lysis of several melanoma cell lines, the role of natural cytotoxicity receptors (NCRs) and DNAM-1 receptors in NK cell recognition and killing of melanoma cells has been recently emphasized. Antibody-mediated masking of NKG2D, NCRs, and DNAM-1 has proven that NKG2D, NCRs, and DNAM-1 frequently cooperate in the lysis of melanoma cells. In this work, we provide an overview of recent advances in the study of melanoma cells' susceptibility to NK cell-mediated lysis and how multiple receptor-ligand interactions participate in melanoma cell elimination. Copyright (C) 2011 S. Karger AG, Basel
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