Journal
JOURNAL OF INNATE IMMUNITY
Volume 2, Issue 2, Pages 160-166Publisher
KARGER
DOI: 10.1159/000232587
Keywords
Adhesin; Airways; Collagen VI; Host-pathogen interaction; Primary adhesion; Respiratory infection; Respiratory pathogen; Streptococcus
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Funding
- Swedish Medical Research Council [2008-7480, 2005-4791]
- Foundations of Crafoord, Bergvall, Greta och Johan Kock, Alfred Osterlund, Konung Gustav V:s 80-Arsfond
- Swedish Society for Medicine
- Medical Faculty, Lund University
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Bacterial engagement of specific host tissue structures can be a means of targeting a pathogen to a particular niche, establishing persistent infections and inducing invasion. In this context, primary adhesion is often the first crucial colonization step allowing pathogens to withstand the mechanical clearing mechanisms of the host. As a consequence, bacteria have evolved adhesins with the capacity to mediate interaction between microorganism and host. Here we describe Collagen VI as a novel target for adherence of Streptococcus pyogenes and Streptococcus pneumoniae. In upper and lower airways this Collagen was distributed in the lamina propria underneath the epithelial basement membrane. Both pathogens exhibited strong affinity to Collagen VI as shown by light and electron microscopy in combination with immunodetection and in vitro binding assays. For S. pyogenes this interaction was mediated by M1 protein. The presented data provide evidence for a previously unrecognized role for Collagen VI in host-pathogen interplay during respiratory tract infection. Copyright (C) 2009 S. Karger AG, Basel
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