Journal
JOURNAL OF INNATE IMMUNITY
Volume 2, Issue 6, Pages 618-624Publisher
KARGER
DOI: 10.1159/000318676
Keywords
Signal transducer and activator of transcription; STAT; Small ubiquitin-like modifier; Sumo; Sumoylation; Post-translational modification
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Funding
- Academy of Finland
- Foundation for Pediatric Research
- Sigrid Juselius Foundation
- Emil Aaltonen Foundation
- Pirkanmaa Hospital District
- Medical Research Council of Academy of Finland
- Tampere University Hospital
- Finnish Cancer Foundation
- Tampere Tuberculosis Foundation
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STAT92E is an essential transcription factor in Drosophila melanogaster for the development of several organs and the immune system. The JAK/STAT pathway employs different evolutionary conserved regulatory mechanisms to control biological processes. Numerous transcription factors in both mammals and invertebrates have been shown to be either activated or inhibited by a covalent modification with a small ubiquitin-like modifier (Sumo). Here, we show that Drosophila STAT92E is modified by Sumo at a single lysine residue 187 in S2 cells. Mutation of Lys187 increases the transcriptional activity of STAT92E, thus suggesting that sumoylation of STAT92E has a repressive role in the regulation of the JAK/STAT pathway in Drosophila melanogaster. Copyright (C) 2010 S. Karger AG, Basel
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