Journal
JOURNAL OF INNATE IMMUNITY
Volume 2, Issue 4, Pages 316-324Publisher
KARGER
DOI: 10.1159/000296915
Keywords
Adaptive immunity; Atherosclerosis; Chronic inflammation; Dyslipidemia; Immune regulation; Innate immunity; Natural killer T cells
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Funding
- NIH [RO1 HL089667]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL088364, R01HL089667, R01HL089310] Funding Source: NIH RePORTER
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Atherosclerosis is a chronic inflammatory disease characterized by dyslipidemia and accumulation of lipids in the arterial intima, with activation of both innate and adaptive immunity. Reciprocally, dyslipidemia associated with atherosclerosis can perturb normal immune function. Natural killer T (NKT) cells are a specialized group of immune cells that share characteristics with both conventional T cells and natural killer cells. However, unlike these cells, NKT cells recognize glycolipid antigens and produce both pro- and anti-inflammatory cytokines upon activation. Because of these unique characteristics, NKT cells have recently been ascribed a role in the regulation of immunity and inflammation, including cardiovascular disease. In addition, NKT cells represent a bridge between dyslipidemia and immune regulation. This review summarizes the current knowledge of NKT cells and discusses the interplay between dyslipidemia and the normal functions of NKT cells and how this might modulate inflammation and atherosclerosis. Copyright (C) 2010 S. Karger AG, Basel
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