Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 210, Issue 4, Pages 593-596Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiu131
Keywords
bacterial vaginosis; multi-species biofilm; virulence determination
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Funding
- European Union (FEDER/COMPETE funds)
- Fundacao para a Ciencia e a Tecnologia [FCOMP-01-0124-FEDER-008991 [PTDC/BIA-MIC/098228/2008], RECI/EBB-EBI/0179/2012 [FCOMP-01-0124-FEDER-027462]]
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Despite the worldwide prevalence of bacterial vaginosis (BV), its etiology is still unknown. Although BV has been associated with the presence of biofilm, the ability of BV-associated bacteria to form biofilms is still largely unknown. Here, we isolated 30 BV-associated species and characterized their virulence, using an in vitro biofilm formation model. Our data suggests that Gardnerella vaginalis had the highest virulence potential, as defined by higher initial adhesion and cytotoxicity of epithelial cells, as well as the greater propensity to form a biofilm. Interestingly, we also demonstrated that most of the BV-associated bacteria had a tendency to grow as biofilms.
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