Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 210, Issue 8, Pages 1306-1310Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiu241
Keywords
factor H; Moraxella catarrhalis; serum resistance
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Funding
- Alfred Osterlund Foundation
- Anna and Edwin Berger Foundation
- Greta and Johan Kock Foundation
- Swedish Medical Research Council [521-2010-4221]
- Physiographical Society (Forssman's Foundation)
- Skane County Council's research and development foundation
- Swiss National Science Foundation
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Factor H is an important complement regulator of the alternative pathway commonly recruited by pathogens to achieve increased rates of survival in the human host. The respiratory pathogen Moraxella catarrhalis, which resides in the mucosa, is highly resistant to the bactericidal activity of serum and causes otitis media in children and respiratory tract infections in individuals with underlying diseases. In this study, we show that M. catarrhalis binds factor H via the outer membrane protein OlpA. M. catarrhalis serum resistance was dramatically decreased in the absence of either OlpA or factor H, demonstrating that this inhibition of the alternative pathway significantly contributes to the virulence of M. catarrhalis.
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