Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 211, Issue 3, Pages 481-485Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiu449
Keywords
CT; [F-18]-FDG; PET; tuberculosis
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Funding
- Swedish Research Council
- Swedish Society for Medical Research
- National Institute of Allergy and Infectious Diseases [RO1AI079590]
- National Institutes of Health [RO1A1035272]
- Howard Hughes Medical Institute
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The presence of cavitary lesions in patients with tuberculosis poses a significant clinical concern due to the risk of infectivity and the risk of antibiotic treatment failure. We describe 2 algorithms that use noninvasive positron emission tomography (PET) and computed tomography (CT) to predict the development of cavitary lesions in rabbits. Analysis of the PET region of interest predicted cavitary disease with 100% sensitivity and 76% specificity, and analysis of the CT region of interest predicted cavitary disease with 83.3% sensitivity and 76.9% specificity. Our results show that restricting our analysis to regions with high [F-18]-fluorodeoxyglucose uptake provided the best combination of sensitivity and specificity.
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