Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 209, Issue -, Pages S16-S19Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit488
Keywords
Bordetella pertussis; whooping cough; animal model; respiratory infection; vaccine; protective immunity; T cells; adjuvant
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Funding
- Science Foundation Ireland
- Bill and Melinda Gates Foundation
- Krembil Foundation
- Canadian Institutes of Health Research
- Saskatchewan Health Research Foundation
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The increasing incidence of whooping cough in many developed countries has been linked with waning immunity induced after immunization with acellular pertussis (aP) vaccines. The rational design of an improved aP vaccine requires a full understanding of the mechanism of protective immunity and preclinical studies in animal models. Infection of mice and pigs with Bordetella pertussis has many features of the infection seen in humans and has already provided valuable information on the roles of innate and adaptive immune responses in protection. Recent findings in these models have already indicated that it may be possible to develop an improved aP vaccine based on a formulation that includes a Toll-like receptor agonist as an adjuvant.
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