Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 208, Issue 2, Pages 192-198Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit116
Keywords
P. falciparum; malaria; cerebral malaria; pathology
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Funding
- Wellcome Trust as part of the Wellcome Trust-Mahidol University-Oxford Tropical Medicine Research Programme
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One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal falciparum malaria was microvascular obstruction. Since then, several alternative hypotheses have been proposed. These formed the basis for adjunctive interventions, which have either been ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami were right.
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