4.7 Article

Sequence Analysis of Transplacentally Acquired Human Herpesvirus 6 DNA Is Consistent With Transmission of a Chromosomally Integrated Reactivated Virus

Journal

JOURNAL OF INFECTIOUS DISEASES
Volume 207, Issue 10, Pages 1585-1589

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit060

Keywords

chromosomally integrated human herpesvirus 6; human herpesvirus; congenital infection; transplacental infection

Funding

  1. Canadian Institutes of Health Research

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The majority of human herpesvirus 6 (HHV-6) congenital infections (86%) originate from germ line transmission of chromosomally integrated HHV-6 (ciHHV-6). To determine whether transplacentally acquired HHV-6 could derive from the transmission of reactivated maternal ciHHV-6, we identified mother-infant pairs in which infants had proven transplacentally acquired HHV-6 and mothers had documented ciHHV-6, and we sequenced and compared the HHV-6 gB gene sequences for each pair. Our data indicate that the gB gene sequence found in each cord blood specimen was identical to that of the corresponding mother but divergent from that of other known HHV-6 isolates. These results are consistent with transplacentally acquired HHV-6 originating from the transmission of reactivated ciHHV-6.

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