Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 209, Issue 2, Pages 243-246Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit589
Keywords
MERS-Coronavirus; serology; population immunity
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Funding
- Municipality of the Holy City of Makkah, Saudi Arabia
- European Management Platform for Emerging and Re-emerging Infectious Disease Entities [223498]
- German Center for Infection Research
- German Ministry for Research and Education
- German Research Council [01KIO701, DR 772/3-1]
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Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel, potentially zoonotic human coronavirus (HCoV). We investigated MERS-CoV antibodies using a staged approach involving an immunofluorescence assay (IFA), a differential recombinant IFA, and a plaque-reduction serum neutralization assay. In 130 blood donors sampled during 2012 in Jeddah and 226 slaughterhouse workers sampled in October 2012 in Jeddah and Makkah, Saudi Arabia, 8 reactive sera were seen in IFA but were resolved to be specific for established HCoVs by discriminative testing. There is no evidence that MERS-CoV circulated widely in the study region in fall 2012, matching an apparent absence of exported disease during the 2012 Hajj.
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