Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 208, Issue 4, Pages 699-704Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit117
Keywords
methamphetamine; blood brain barrier; Cryptococcus neoformans
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Funding
- Center for AIDS Research, Albert Einstein College of Medicine and Montefiore Medical Center, through the National Institutes of Health (NIH) [AI-51519]
- Benjamin Cummings/MACUB Student Research Award
- Long Island University-Post Faculty Research Committee Award
- Faculty Research Committee Undergraduate Research Award
- Irma T. Hirschl/Monique Weill-Caulier Trust Research award
- National Institute of Allergy and Infectious Diseases, NIH [5K22A1087817-02]
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Methamphetamine (METH) is a drug of abuse that is a potent and highly addictive central nervous system (CNS) stimulant. The blood brain barrier (BBB) is a unique interface that in part functions to prevent microbial invasion of the CNS. The effects of METH on brain vasculature have not been studied extensively. We hypothesized that METH alters the BBB integrity, increasing susceptibility to CNS infection. Using a murine model of METH administration, we demonstrated that METH alters BBB integrity and modifies the expression of tight junction and adhesion molecules. Additionally, we showed that BBB disruption accelerates transmigration of the neurotropic fungus Cryptococcus neoformans into the brain parenchyma after systemic infection. Furthermore, METH-treated mice displayed increased mortality as compared to untreated animals. Our findings provide novel evidence of the impact of METH abuse on the integrity of the cells that comprise the BBB and protect the brain from infection.
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