Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 208, Issue -, Pages S131-S136Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit318
Keywords
HIV; humanized mice; mucosal infection
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Funding
- National Institutes of Health [P01 AI078897]
- Swiss National Science foundation [PBGEP3-125895]
- Ragon Institute of MGH, MIT, and Harvard
- Swiss National Science Foundation (SNF) [PBGEP3-125895] Funding Source: Swiss National Science Foundation (SNF)
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The majority of human immunodeficiency virus type 1 (HIV-1) infections occur by sexual exposure, and vaginal transmission accounts for more than half of all newly acquired infections. Studies of vaginal transmission of simian immunodeficiency virus to nonhuman primates (NHPs) have suggested an important role for immune cell trafficking in the establishment of infection as well is in the process of viral dissemination. However, NHP models do not permit the study of HIV transmission and dissemination. The improvement of humanized mouse models with robust human immune cell reconstitution of the female genital tract renders these mice susceptible to intravaginal HIV infection. Thus humanized mouse models of HIV vaginal infection will allow the study of the mechanisms involved in HIV transmission and dissemination in vivo.
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