Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 208, Issue 4, Pages 564-572Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit210
Keywords
Alzheimer's disease; cytomegalovirus; interferon-gamma; CD28-/CD57+T cells; amyloid-beta
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Funding
- National Institute of Aging, National Institutes of Health [P30AG10161, R01AG15819]
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Serum, cerebrospinal fluid (CSF), and cryopreserved lymphocytes from subjects in the Rush Alzheimer's Disease Center Religious Orders Study were analyzed for associations between cytomegalovirus (CMV) infection and clinical and pathological markers of Alzheimer disease. CMV antibody levels were associated with neurofibrillary tangles (NFTs). CSF interferon gamma was only detected in seropositive subjects and was significantly associated with NFTs. The percentage of senescent T cells (CD4+ or CD8+CD28-CD57+) was significantly higher for CMV-seropositive as compared to CMV-seronegative subjects and was marginally associated with the pathologic diagnosis of Alzheimer disease (CD4+) or amyloid-beta (CD8+). Immunocytochemical analysis showed induction of amyloid-beta in human foreskin fibroblasts (HFFs) infected with each of 3 clinical CMV strains. In the same subjects, there was no association of herpes simplex virus type 1 (HSV-1) antibody levels with CMV antibody levels or clinical or pathological markers of Alzheimer disease. HSV-1 infection of HFFs did not induce amyloid-beta. These data support an association between CMV and the development of Alzheimer disease.
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