Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 209, Issue 7, Pages 1028-1031Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit468
Keywords
genetics; H1N1; Influenza; LRTI; infectious disease; IFITM3; association study; Virus
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Funding
- GRACE project (Sixth Framework Programme of the European Commission) [LSHM-CT-2005-518226]
- Wellcome Trust [090532/Z/09/Z]
- Medical Research Council [G1001712, G1100449] Funding Source: researchfish
- National Institute for Health Research [CL-2006-13-003] Funding Source: researchfish
- MRC [G1001712, G1100449] Funding Source: UKRI
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Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM 1,2, and 3) are viral restriction factors that mediate cellular resistance to several viruses. We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influenza and severe pneumonia, and >5000 individuals comprising patients with community-acquired mild lower respiratory tract infection and matched controls of Caucasian ancestry. We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptibility to severe H1N1 infection.
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