Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 207, Issue 7, Pages 1144-1147Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit003
Keywords
Influenza vaccine; pregnancy; pneumococcal conjugate vaccine; influenza-like illness
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Funding
- Bill and Melinda Gates Foundation [HRN-A-0096-90006-00]
- US Agency for International Development
- Department of Health and Human Services
- National Vaccine Program Office
- Wyeth Pharmaceuticals
- Thrasher Research Fund
- Aventis Pasteur
- International Centre for Diarrheal Disease Research
- Bloomberg School of Public Health at Johns Hopkins University
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A 2 x 2 factorial trial was performed to determine the efficacy of antennal influenza vaccination of mothers plus pneumococcal conjugate vaccination of their infants against respiratory illness during early infancy. The efficacy of trivalent inactivated influenza vaccine (TIV; delivered to mothers) plus 7-valent pneumococcal vaccine (PCV7; delivered to infants) was higher than the efficacy of TIV alone or PCV7 alone. During the period of the study in which influenza was circulating, the efficacy of TIV plus PCV7 was 72.4% (95% confidence interval, 30.2%-89.1%) against febrile respiratory illness and 66.4% (95% CI, 14.3%-86.9%) against medically attended acute respiratory illness. Clinical Trials registration NCT00142389.
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