Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 207, Issue 6, Pages 903-906Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis924
Keywords
Zimbabwean population; HIV; HLA-G; polymorphism; survival
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Funding
- Copenhagen University Hospital, Rigshospitalet
- Research Board, University of Zimbabwe
- Essential National Health Research Fund of the Ministry of Health and Child Welfare of Zimbabwe
- Danish AIDS Foundation
- Danish Embassy in Zimbabwe
- DANIDA (Danish International Development Agency) Health Programme in Zimbabwe
- UNICEF/United Nations Development Programme/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases [A30670]
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We aimed to evaluate whether the HLA-G 14-base pair (bp) polymorphism (rs16375) has an impact on human immunodeficiency virus HIV progression and survival in an antiretroviral therapy-naive Zimbabwean cohort (n = 312). Rs16375 was genotyped using a competitive allele-specific polymerase chain reaction system; CD4 cell counts and HIV RNA were measured with flow cytometry and commercially available polymerase chain reaction; survival was followed up for 4.3 years. The homozygous HLA-G -14-bp genotype is associated with higher viral load (P = .004), lower CD4 cell count (P = .01), and increased mortality (hazard ratio, 1.9; 95% confidence interval, 1.033-3.522; P = .04) compared with HLA-G +14-bp carriers.
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