Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 206, Issue 11, Pages 1763-1767Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis588
Keywords
-
Categories
Funding
- Canadian Institutes of Health Research
- Agence Nationale de la Recherche
- Ordre de Malte
- Heiser Fondation
- Fondation Pour la Recherche Medicale
- Canadian Genetic Diseases Network
Ask authors/readers for more resources
A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and NOD2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn's disease and leprosy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available