Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 205, Issue 8, Pages 1305-1310Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis186
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Funding
- University of New South Wales [455479]
- National Health and Medical Research Council of Australia [510259]
- Stillbirth Foundation of Australia
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Congenital infection with cytomegalovirus (CMV) can induce immune responses and placental damage. By use of immunoassay panels, 27 cytokines were assessed in midtrimester amniotic fluid from 8 patients with congenital CMV, in midtrimester sera from 12 pregnant women with primary CMV infection, and in amniotic fluid and serum from uninfected maternal controls. Levels of the cytokines tumor necrosis factor alpha, interleukin 1 beta, interleukin 12, and interleukin 17; the chemokines CCL2, CCL4, and CXCL10; and the growth factors granulocyte-macrophage colony-stimulating factor and platelet-derived growth factor bb were significantly elevated in amniotic fluid from congenital CMV patients (P < .01). Only CXCL10 was significantly higher in sera from CMV-infected pregnant women. CMV infection during pregnancy is associated with a shift in cytokine expression toward a proinflammatory state.
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