4.7 Article

The Nonsteroidal Antiinflammatory Drug Diclofenac Potentiates the In Vivo Activity of Caspofungin Against Candida albicans Biofilms

Journal

JOURNAL OF INFECTIOUS DISEASES
Volume 206, Issue 11, Pages 1790-1797

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis594

Keywords

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Funding

  1. Fonds Wetenschappelijk Onderzoek-Vlaanderen [G.0896.10, G0804.11, 1.5.141.09N, 1.2.B62.12N]
  2. Industrial Research Fund
  3. Katholieke Universiteit Leuven [IOF/KP/11/007, PDMK/11/089]
  4. Katholieke Universiteit Leuven (IOF-M)

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In this study, we demonstrated that in vitro Candida albicans biofilms grown in the presence of diclofenac showed increased susceptibility to caspofungin. These findings were further confirmed using a catheter-associated biofilm model in rats. C. albicans-inoculated catheters retrieved from rats that were treated with both diclofenac and caspofungin contained significantly fewer biofilm cells and showed no visible biofilms inside the catheter lumens, as documented by scanning electron microscopy, as compared to catheters retrieved from rats receiving only caspofungin or diclofenac. This report indicates that diclofenac could be useful in combination therapy with caspofungin to treat C. albicans biofilm-associated infections.

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