Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 205, Issue -, Pages S368-S374Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis201
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Funding
- National Institutes of Health [K23 HL092792, R01 HL048743]
- Harvard University Center for AIDS Research
- Bristol-Myers Squibb
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Complications of atherosclerosis, including myocardial infarction and stroke, are the leading cause of death and disability worldwide. Recent data strongly implicate cardiovascular death as a contributor to mortality among patients with human immunodeficiency virus (HIV) infection, with evidence suggesting increased incidence of atherosclerosis among these patients. Therefore, greater understanding of atherosclerotic mechanisms and how these responses may be similar or distinct in HIV-infected patients is needed. Key concepts in atherosclerosis are reviewed, including the evidence that inflammation and abnormal metabolism are major drivers of atherosclerosis, and connected to the current literature regarding atherosclerosis in the context of HIV.
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