Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 207, Issue 2, Pages 319-322Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis674
Keywords
monoclonal antibodies; Chikungunya virus; protection; in vivo; therapeutic; prophylactic
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Funding
- Singapore Immunology Network, Biomedical Research Council, Agency for Science, Technology, and Research
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Chikungunya virus (CHIKV) is an alphavirus prevalent in tropical regions. It causes an acute febrile disease that, in elderly individuals and newborns, is often associated with severe complications. We previously reported the isolation and characterization of 2 human monoclonal antibodies neutralizing CHIKV in vitro: 5F10 and 8B10. Here, we tested their efficacy in vivo as prophylactic and therapeutic treatments of CHIKV infection in AGR129 mice. In both settings, 5F10 and 8B10 were able to significantly delay CHIKV-driven lethality. Our results support the development of prophylactic and therapeutic treatments for CHIKV infection, using a combination of 5F10 and 8B10.
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