Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 203, Issue 4, Pages 545-548Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiq086
Keywords
-
Categories
Funding
- European Development Regional Fund A way to achieve Europe (ERDF)
- Spanish Network for the Research in Infectious Diseases, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovacion, Spain [REIPI RD06/0008]
- Autonomous government of Madrid [COMBACT S-BIO-0260/2006]
Ask authors/readers for more resources
Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in vitro development of resistance to colistin. The colistin-resistant strain has lower affinity for colistin, reduced in vivo fitness (competition index, .016), and decreased virulence, both in terms of mortality (0% lethal dose, 6.9 vs 4.9 log colony-forming units) and survival in a mouse model of peritoneal sepsis. These results may explain the low incidence and dissemination of colistin resistance in A. baumannii in clinical settings.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available