Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 204, Issue -, Pages S776-S784Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir364
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Funding
- government of Gabon, Total-Fina-Elf Gabon
- Ministere des Affaires Etrangeres et Europeennes de la France
- Global Viral Forecasting
- U.S. Department of Defense Global Emerging Infections, Surveillance and Response Systems (DoD GEIS)
- Defense Threat Reduction Agency (DTRA)
- Google.org
- Skoll Foundation
- U.S. Agency for International Development Emerging & Pandemic Threats PREDICT Cooperative Agreement
- Science and Technology Directorate, U.S. Department of Homeland Security
- Fogarty International Center, NIH
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Methods. Viruses of each outbreak were isolated and the full-length genomes were characterized. Phylogenetic analysis was then undertaken to characterize the relationships with previously described viruses. Results. The 2 Luebo viruses are nearly identical but are not related to lineage A viruses known in DRC or to descendants of the lineage B viruses encountered in the Gabon-Republic of the Congo area, with which they do, however, share a common ancestor. Conclusions. Our findings strongly suggest that the Luebo 2007 outbreak did not result from viral spread from previously identified foci but from an independent viral emergence. The previously identified epidemiological link with migratory bat species known to carry Zaire ebolavirus RNA support the hypothesis of viral spillover from this widely dispersed reservoir. The high level of similarity between the Luebo2007 and Luebo2008 viruses suggests that local wildlife populations (most likely bats) became infected and allowed local viral persistence and reemergence from year to year.
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