Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 204, Issue 1, Pages 135-138Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir208
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Funding
- National Institute of Allergy and Infectious Diseases, National Institutes of Health
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Residual plasma viremia (<50 copies/mL) persists in certain human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART); however, the relationship between the degree of residual plasma viremia, the size of HIV reservoirs, and the level of immune activation has not been delineated. Here, we demonstrate that residual plasma viremia correlates with the size of the CD4(+) T cell viral reservoir, but not with markers of immune activation, suggesting that reactivation of the latent viral reservoir may not be the sole source of residual plasma viremia. Novel therapeutic strategies aimed at targeting the source of residual viremia may be necessary to achieve viral eradication.
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