Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 203, Issue 8, Pages 1096-1100Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiq173
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Funding
- Swedish Cancer Society [2098]
- Swedish Research Council [K 2001-57x-21044-01-3]
- Clinical Research Committee of the Skane County Council [M2007/1656]
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To validate whether Merkel cell polyomavirus (MCV) serology correlates with MCV infection, we compared real-time polymerase chain reaction results for MCV DNA on fresh-frozen biopsy specimens from various skin lesions and healthy skin from 434 patients to MCV serology results using viruslike particles (VLPs) and MCV neutralization assays. Sixty- five percent of participants were MCV seropositive and 18% were MCV DNA positive. The presence of antibodies was correlated with the presence of virus DNA (odds ratio, 27.85 [95% confidence interval, 6.6-166.5]), with 97% of patients who tested positive for MCV DNA being MCV seropositive. VLP antibody levels correlated to neutralization titers (r = 5.72), and high antibody levels correlated to high MCV load (P<.01).
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