Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 203, Issue 5, Pages 666-673Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiq093
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Funding
- National Institutes of Health [HHSN-272200800003C, HHSN272200800005C, HHSN272200800004C]
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Methods. The influence of schedule on the antibody response to 2 doses of H5 vaccines (one a clade 1 hemagglutinin protein [HA] vaccine and one a clade 2 HA vaccine) containing 90 mu g of antigen was evaluated in healthy adults 18-49 years of age. Results. Two doses of vaccine were required to induce antibody titers >= 1:10 in most subjects. Accelerated schedules were immunogenic, and antibody developed after vaccinations on days 0 and 7, 0 and 14, and 0 and 28, with the day 0 and 7 schedule inducing lower titers than those induced with the other schedules. With mixed vaccine schedules of clade 1 followed by clade 2 vaccine administration, the first vaccination primed for a heterologous boost. The heterologous response was improved when the second vaccination was given 6 months after the first, compared with the response when the second vaccination was given after an interval of 1 month. Conclusions. An accelerated vaccine schedule of injections administered at days 0 and 14 was as immunogenic as a vaccine schedule of injections at days 0 and 28, but both schedules were inferior to a vaccine schedule of injections administered at 0 and 6 months for priming for heterologous vaccine boosting. Clinical Trial Registry Number: NCT00703053.
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