4.7 Article

HTLV-2 APH-2 Expression Is Correlated With Proviral Load but APH-2 Does Not Promote Lymphocytosis

Journal

JOURNAL OF INFECTIOUS DISEASES
Volume 205, Issue 1, Pages 82-86

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir708

Keywords

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Funding

  1. Ecole Normale Superieure de Lyon
  2. Ministere de la Recherche
  3. National Heart Lung and Blood Institute (NHLBI) [K24-HL-75036, 2R01-HL-62235]
  4. l'Association de Recherche sur le Cancer
  5. l'Institut National du Cancer
  6. INSERM
  7. l'Ecole Normale Superieure de Lyon

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We recently discovered the antisense protein of human T-cell leukemia virus (HTLV) type 2 (APH-2), whose messenger RNA is encoded by the antisense strand of the HTLV-2 genome. We quantified proviral load, level of tax, and APH-2 in a series of blood samples obtained from a cohort of HTLV-2 carriers. We determined whether APH-2 promotes cell proliferation. APH-2 was detectable in most samples tested and was correlated with proviral load. APH-2 levels were not correlated with lymphocyte count in vivo, consistent with the inability of APH-2 to promote cell proliferation in vitro. APH-2 does not promote cell proliferation and does not cause lymphocytosis.

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