Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 204, Issue 7, Pages 1026-1030Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir470
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Funding
- Australian National Health and Medical Research Council [303404]
- Australia India Biotechnology Fund [BF030013]
- Australian Research Council
- National Health and Medical Research Council
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Chikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic disease in humans. Using a mouse model of CHIKV arthritis and myositis, we show that tumor necrosis factor-alpha, interferon-gamma, and monocyte chemotactic protein 1 (MCP-1) were dramatically induced in tissues from infected mice. The same factors were detected in the serum of patients with CHIKV-induced polyarthralgia and polyarthritis, with MCP-1 levels being particularly elevated. Bindarit (MCP inhibitor) treatment ameliorated CHIKV disease in mice. Histological analysis of muscle and joint tissues showed a reduction in inflammatory infiltrate in infected mice treated with bindarit. These results suggest that bindarit may be useful in treating CHIKV-induced arthritides in humans.
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