4.7 Article

International Spread of an Epidemic Population of Salmonella enterica Serotype Kentucky ST198 Resistant to Ciprofloxacin

Journal

JOURNAL OF INFECTIOUS DISEASES
Volume 204, Issue 5, Pages 675-684

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir409

Keywords

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Funding

  1. Institut Pasteur
  2. Danish Research Agency [274-05-0117]
  3. World Health Organization Global Foodborne Infections Network
  4. Institut National de la Recherche Agronomique
  5. Health Protection Agency
  6. Statens Serum Institute
  7. Centers for Disease Control and Prevention
  8. Institut Pasteur du Maroc
  9. University of Ibadan
  10. Agence Francaise de Securite Sanitaire des Aliments
  11. Reseau international des Instituts Pasteur et instituts associes
  12. Institut de Veille Sanitaire
  13. Science Foundation of Ireland [05/FE1/B882]

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National Salmonella surveillance systems from France, England and Wales, Denmark, and the United States identified the recent emergence of multidrug-resistant isolates of Salmonella enterica serotype Kentucky displaying high-level resistance to ciprofloxacin. A total of 489 human cases were identified during the period from 2002 (3 cases) to 2008 (174 cases). These isolates belonged to a single clone defined by the multilocus sequence type ST198, the XbaI-pulsed-field gel electrophoresis cluster X1, and the presence of the Salmonella genomic island 1 variant SGI1-K. This clone was probably selected in 3 steps in Egypt during the 1990s and the early 2000s and has now spread to several countries in Africa and, more recently, in the Middle East. Poultry has been identified as a potential major vehicle for infection by this clone. Continued surveillance and appropriate control measures should be implemented by national and international authorities to limit the spread of this strain.

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