Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 203, Issue 9, Pages 1282-1291Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir012
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Funding
- National Institutes of Health [P01 AI034533]
- United States Army Medical Research and Materiel Command
- National Institutes of Health (Diabetes Endocrinology Research Center [DERC] [DK32520]
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The pathophysiology of dengue virus infection remains poorly understood, although secondary infection is strongly associated with more severe disease. In the present study, we performed a nested, case-control study comparing the responses of pre-illness peripheral blood mononuclear cells between children who would subsequently develop either subclinical or symptomatic secondary infection 6-11 months after the baseline blood samples were obtained and frozen. We analyzed intracellular cytokine production by CD4(+) and CD8(+) cells in response to stimulation with dengue antigen. We found higher frequencies of dengue virus-specific TNF alpha, IFN gamma-, and IL-2-producing T cells among schoolchildren who subsequently developed subclinical infection, compared with those who developed symptomatic secondary dengue virus infection. Although other studies have correlated immune responses during secondary infection with severity of disease, to our knowledge this is the first study to demonstrate a pre-infection dengue-specific immune response that correlates specifically with a subclinical secondary infection.
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