Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 204, Issue 12, Pages 1843-1847Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir647
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Funding
- National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics
- National Institute on Drug Abuse [R01-DA09532, R01-DA12109, R01-DA13245]
- National Cancer Institute, National Institutes of Health [N01-CO-12400]
- Substance Abuse and Mental Health Services Administration [H79-TI12103]
- San Francisco Department of Public Health
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Among 1369 Urban Health Study participants, we evaluated genetic models for the association of IL28B genotype (rs12979860 and rs8099917) with hepatitis C virus (HCV) clearance. For rs12979860, adjusted odds ratios for spontaneous HCV clearance were as follows: IL28B-CC, 3.88 (P < .001); IL28B-CT, 1.48 (P = .08). On the basis of Akaike information criteria values and chi(2) tests, a supra-additive (quadratic) model fit these data best. Models based on rs8099917 provided poorer fit. Evidence that a supra-additive rs12979860-based model best fits the association of IL28B-genotype with HCV clearance may improve clinical prediction models and foster a better understanding of functional mechanisms underlying this association.
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