Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 204, Issue 6, Pages 854-863Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir440
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Funding
- Novartis
- Sanofi Pasteur
- GlaxoSmithKline
- Wyeth
- CSL
- Cubist Pharmaceuticals
- Merck
- National Institutes of Health [HHSN272200800004C, HHSN272200800057C, HHSN27220080000C, HHSN272200800002C, HHSN272200800003C, N01-AI-30063]
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Background. Although pregnant women are at increased risk of severe illness following influenza infection, there is relatively little information on the immunogenicity of influenza vaccines administered during pregnancy. Methods. We conducted a clinical trial that enrolled 120 pregnant women in which participants were randomly assigned to receive an inactivated 2009 H1N1 influenza vaccine containing either 25 mu g or 49 mu g of hemagglutinin (HA) in a 2-dose series with a 21-day period between administration of the first and second doses. Results. Following the first vaccination, HA inhibition (HAI) titers of >= 1:40 were detected in 93% (95% confidence interval [CI], 82%-98%) of subjects who received the 25-mu g dose and 97% (95% CI, 88%-100%) of subjects receiving the 49-mu g dose. In cord blood samples, HAI titers of >= 1:40 were found in 87% (95% CI, 73%-96%) of samples from the 25-mu g dose group and in 89% (95% CI, 76%-96%) from the 49-mu g dose group. Microneutralization titers tended to be higher than HAI titers, but the patterns of response were similar. Conclusions. In pregnant women, 1 dose of an inactivated 2009 H1N1 influenza vaccine containing 25 mu g of HA elicited an antibody response typically associated with protection against influenza infection. Efficient transplacental transfer of antibody was also documented.
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